.nlm-p{display:block;margin-bottom:20px;}.nlm-italic{font-style:italic;}.nlm-bold{font-weight:bold;}
#lightbox{position:absolute;top:40px;left:0;width:100%;z-index:100;text-align:center;line-height:0;}#lightbox a img{border:none;}#outerImageContainer{position:relative;background-color:#fff;width:250px;height:250px;margin:0 auto;min-width:240px;overflow:hidden;}#imageContainer,#frameContainer,#modalContainer{padding:10px;}#modalContainer{line-height:1em;overflow:auto;}#loading{height:25%;width:100%;text-align:center;line-height:0;position:absolute;top:40%;left:45%;}#hoverNav{position:absolute;top:0;left:0;height:100%;width:100%;z-index:10;}#imageContainer>#hoverNav{left:0;}#frameHoverNav{z-index:10;margin-left:auto;margin-right:auto;width:20%;position:absolute;bottom:0px;height:45px;}#imageData>#frameHoverNav{left:0;}#hoverNav a,#frameHoverNav a{outline:none;}#prevLink,#nextLink{width:49%;height:100%;background:transparent url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/blank.gif) no-repeat;display:block;}#prevLink,#framePrevLink{left:0;float:left;}#nextLink,#frameNextLink{right:0;float:right;}#prevLink:hover,#prevLink:visited:hover,#prevLink.force_show_nav,#framePrevLink{background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/prev.gif) left 15% no-repeat;}#nextLink:hover,#nextLink:visited:hover,#nextLink.force_show_nav,#frameNextLink{background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/next.gif) right 15% no-repeat;}#prevLink:hover.force_show_nav,#prevLink:visited:hover.force_show_nav,#framePrevLink:hover,#framePrevLink:visited:hover{background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/prev_hover.gif) left 15% no-repeat;}#nextLink:hover.force_show_nav,#nextLink:visited:hover.force_show_nav,#frameNextLink:hover,#frameNextLink:visited:hover{background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/next_hover.gif) right 15% no-repeat;}#framePrevLink,#frameNextLink{width:45px;height:45px;display:block;position:absolute;bottom:0px;}#imageDataContainer{font:10px Verdana,Helvetica,sans-serif;background-color:#fff;margin:0 auto;line-height:1.4em;min-width:240px;}#imageData{padding:0 10px;}#imageData #imageDetails{width:70%;float:left;text-align:left;}#imageData #caption{font-weight:bold;}#imageData #numberDisplay{display:block;clear:left;padding-bottom:1.0em;}#imageData #lightbox2-node-link-text{display:block;padding-bottom:1.0em;}#imageData #bottomNav{height:66px;}.lightbox2-alt-layout #imageData #bottomNav,.lightbox2-alt-layout-data #bottomNav{margin-bottom:60px;}#lightbox2-overlay{position:absolute;top:0;left:0;z-index:90;width:100%;height:500px;background-color:#000;}#overlay_default{opacity:0.6;}#overlay_macff2{background:transparent url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/overlay.png) repeat;}.clearfix:after{content:".";display:block;height:0;clear:both;visibility:hidden;}* html>body .clearfix{display:inline;width:100%;}* html .clearfix{height:1%;}#bottomNavClose{display:block;background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/close.gif) left no-repeat;margin-top:33px;float:right;padding-top:0.7em;height:26px;width:26px;}#bottomNavClose:hover{background-position:right;}#loadingLink{display:block;background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/loading.gif) no-repeat;width:32px;height:32px;}#bottomNavZoom{display:none;background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/expand.gif) no-repeat;width:34px;height:34px;position:relative;left:30px;float:right;}#bottomNavZoomOut{display:none;background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/contract.gif) no-repeat;width:34px;height:34px;position:relative;left:30px;float:right;}#lightshowPlay{margin-top:42px;float:right;margin-right:5px;margin-bottom:1px;height:20px;width:20px;background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/play.png) no-repeat;}#lightshowPause{margin-top:42px;float:right;margin-right:5px;margin-bottom:1px;height:20px;width:20px;background:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/modules/contrib/lightbox2/images/pause.png) no-repeat;}.lightbox2-alt-layout-data #bottomNavClose,.lightbox2-alt-layout #bottomNavClose{margin-top:93px;}.lightbox2-alt-layout-data #bottomNavZoom,.lightbox2-alt-layout-data #bottomNavZoomOut,.lightbox2-alt-layout #bottomNavZoom,.lightbox2-alt-layout #bottomNavZoomOut{margin-top:93px;}.lightbox2-alt-layout-data #lightshowPlay,.lightbox2-alt-layout-data #lightshowPause,.lightbox2-alt-layout #lightshowPlay,.lightbox2-alt-layout #lightshowPause{margin-top:102px;}.lightbox_hide_image{display:none;}#lightboxImage{-ms-interpolation-mode:bicubic;}
div.panel-pane div.admin-links{font-size:xx-small;margin-right:1em;}div.panel-pane div.admin-links li a{color:#ccc;}div.panel-pane div.admin-links li{padding-bottom:2px;background:white;z-index:201;}div.panel-pane div.admin-links:hover a,div.panel-pane div.admin-links-hover a{color:#000;}div.panel-pane div.admin-links a:before{content:"[";}div.panel-pane div.admin-links a:after{content:"]";}div.panel-pane div.panel-hide{display:none;}div.panel-pane div.panel-hide-hover,div.panel-pane:hover div.panel-hide{display:block;position:absolute;z-index:200;margin-top:-1.5em;}div.panel-pane div.node{margin:0;padding:0;}div.panel-pane div.feed a{float:right;}
#hw-email-link > .pane-content{display:inline;}
div.ui-cluetip{font-size:1em;}.ui-cluetip-header,.ui-cluetip-content{padding:12px;}.ui-cluetip-header{font-size:1em;margin:0;overflow:hidden;}.cluetip-title .cluetip-close{float:right;position:relative;}.cluetip-close img{border:0;}#cluetip-waitimage{width:43px;height:11px;position:absolute;background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/wait.gif);}.cluetip-arrows{display:none;position:absolute;top:0;left:-11px;width:11px;height:22px;background-repeat:no-repeat;background-position:0 0;border-width:0;}.cluetip-extra{display:none;}.cluetip-default,.cluetip-default .cluetip-outer{background-color:#d9d9c2;}.cluetip-default .ui-cluetip-header{background-color:#87876a;}div.cluetip-default .cluetip-arrows{border-width:0;background:transparent none;}div.clue-right-default .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/darrowleft.gif);}div.clue-left-default .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/darrowright.gif);left:100%;margin-right:-11px;}div.clue-top-default .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/darrowdown.gif);top:100%;left:50%;margin-left:-11px;width:22px;height:11px;}div.clue-bottom-default .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/darrowup.gif);top:-11px;left:50%;margin-left:-11px;width:22px;height:11px;}.cluetip-jtip{background-color:#fff;}.cluetip-jtip .cluetip-outer{border:2px solid #ccc;position:relative;}.cluetip-jtip .cluetip-inner{padding:5px;display:inline-block;}.cluetip-jtip div.cluetip-close{text-align:right;margin:0 5px 0;color:#900;}.cluetip-jtip .ui-cluetip-header{background-color:#ccc;padding:6px;}div.cluetip-jtip .cluetip-arrows{border-width:0;background:transparent none;}div.clue-right-jtip .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/arrowleft.gif);}div.clue-left-jtip .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/arrowright.gif);left:100%;margin-right:-11px;}div.clue-top-jtip .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/arrowdown.gif);top:100%;left:50%;width:22px;height:11px;margin-left:-11px;}div.clue-bottom-jtip .cluetip-arrows{background-image:url(https://d1efy7v7gfbrqu.cloudfront.net/sites/all/libraries/cluetip/images/arrowup.gif);top:-11px;left:50%;width:22px;height:11px;margin-left:-11px;}.cluetip-rounded{-webkit-border-radius:6px;-moz-border-radius:6px;border-radius:6px;background-color:#fff;border:1px solid #ccc;}.cluetip-rounded .cluetip-outer{-webkit-border-radius:6px;-moz-border-radius:6px;border-radius:6px;background-color:#fff;}.cluetip-rounded  .cluetip-arrows{border-color:#ccc;}div.cluetip-rounded  .cluetip-arrows{font-size:0;line-height:0%;width:0;height:0;border-style:solid;background:transparent none;}div.clue-right-rounded .cluetip-arrows{border-width:11px 11px 11px 0;border-top-color:transparent;border-bottom-color:transparent;border-left-color:transparent;}div.clue-left-rounded .cluetip-arrows{left:100%;margin-right:-11px;border-width:11px 0 11px 11px;border-top-color:transparent;border-right-color:transparent;border-bottom-color:transparent;}div.clue-top-rounded .cluetip-arrows{top:100%;left:50%;border-width:11px 11px 0 11px;border-right-color:transparent;border-bottom-color:transparent;border-left-color:transparent;}.clue-bottom-rounded .cluetip-arrows{top:-11px;left:50%;border-width:0 11px 11px 11px;border-top-color:transparent;border-right-color:transparent;border-left-color:transparent;}.cluetip-rounded .cluetip-title,.cluetip-rounded .cluetip-inner{zoom:1;}
.loading{display:block;margin:0 auto;}
.highwire-markup ul{padding-left:40px;}.highwire-markup .contributors{text-align:left;}.highwire-markup div.contributors ol.contributor-list{font-weight:bold;list-style:none;margin:15px 0 0 0;padding:0;text-align:left;white-space:normal;}.highwire-markup div.contributors ol.contributor-list li{display:inline;line-height:1.1em;padding:0;margin:0;text-align:left;white-space:normal;}.highwire-markup div.contributors ol li a{border:0;font-weight:normal;text-decoration:none;vertical-align:.2em;}.highwire-markup .affiliation-list-reveal{margin-top:10px;}.highwire-markup .affiliation-list-reveal a.view-more{float:left;margin:0 5px;padding:0;text-align:center;width:0.9em;}.highwire-markup .affiliation-list-reveal a.view-more{border:0;display:block;font-size:1.5em;line-height:0.9em;padding:0 5px;}.highwire-markup div.contributors ol.affiliation-list{font-weight:normal;list-style:none;}.highwire-markup .hideaffil{left:-9999px;position:absolute;width:5000px;}.highwire-markup div.contributors ol.affiliation-list li{display:list-item;margin-left:5px;padding-left:0;}.highwire-markup div.contributors ol.affiliation-list li address{border:0;display:inline;font-style:italic;padding:0;margin:0;}.highwire-markup div.contributors ol.corresp-list{list-style:none;padding:0;margin:0;}.highwire-markup div.contributors ol.corresp-list li{margin-left:0;}.highwire-markup div.contributors li.corresp a{font-weight:normal;text-decoration:none;vertical-align:0em;}.highwire-markup .corresp-list .corresp-label{font-size:0.85em;line-height:0;vertical-align:super;}.highwire-markup #content-block-markup ul.history-list{list-style-type:none;margin:5px 0;padding:0 0 0;}.highwire-markup .article div.section{border:0;clear:both;margin:0;padding:0;}.highwire-markup .article div.section h2{border:0;border-bottom:2px dotted #999;font-size:125%;margin:10px 0 10px 0;}.highwire-markup a.xref-bibr,.highwire-markup a.xref-fig,.highwire-markup a.xref-table,.highwire-markup a.xref-list{font-weight:bold;text-decoration:none;}.highwire-markup .article div.section h3,.highwire-markup .article div.section h4{display:inline;font-size:1.1em;font-weight:bold;padding:0;margin:0;margin-right:5px;text-transform:none;}.highwire-markup .article div.section h3{padding-bottom:10px;}.highwire-markup .article div.section h4{font-style:italic;}.highwire-markup ul.kwd-group{border-top:1px dotted #999;border-bottom:1px dotted #999;font-size:.833em;font-weight:bold;line-height:2;padding:.5em;margin:0;margin-bottom:1em;text-align:center;}.highwire-markup ul.kwd-group li.kwd{background-color:#d8d8d8;display:inline;padding:.5em;margin:0 .7em;line-height:2;white-space:normal;}.highwire-markup .article div.section{border:0;clear:both;margin:0;padding:0;}.highwire-markup .section .list-simple li{list-style:none;}.highwire-markup div.article .fig,.highwire-markup div.article .table{margin:1em 20px 1em 20px;clear:both;}.highwire-markup .fig-inline,.highwire-markup .table-inline{font-size:.85em;border:1px dotted #999;background-color:white;height:auto;padding:1em;margin:1em 10px;text-align:center;float:left;}.highwire-markup div.fig a.in-nw-vis{display:inline;}.highwire-markup .fig-caption,.highwire-markup .graphic-caption,.highwire-markup .table-caption,.highwire-markup .table-foot,.highwire-markup .media-caption{line-height:1.4;}.highwire-markup .fig-label,.highwire-markup .table-label{font-weight:bold;}.highwire-markup .figure-callout{margin-bottom:0.6em;text-align:center;}.highwire-markup .figure-callout-links a{background:#F5F5F5;border:1px solid #DDD;-moz-border-radius:4px;-webkit-border-radius:4px;border-radius:4px;display:inline-block;font-size:0.85em;padding:0.5em;}.highwire-markup .figure-callout-links a:hover{background:#FCFCFC;}.highwire-markup .figure-callout-links span{display:inline-block;height:20px;line-height:20px;vertical-align:middle;}.highwire-markup .figure-callout-icon{height:20px;margin-right:5px;vertical-align:middle;width:20px;}#colorbox #cboxTitle{background:rgba(83,83,83,0.9);color:#FFF;}.highwire-markup div.caption-clear{clear:both;}.highwire-markup ul.copyright-statement{list-style-type:none;}.highwire-markup div.fn-group ul{list-style:none;margin:0;padding:0;padding-top:5px;}.highwire-markup div.bio{margin-top:1em;}.highwire-markup div.fn-group ul li{border-bottom:1px solid #C8C8C8;margin:0 auto;padding:.5em 0;text-align:left;width:95%;}.highwire-markup div.fn-group ul li p{margin-bottom:0;}.highwire-markup #content-block-markup div.fn-group ul li p{margin:.5em 0;padding:0;}.highwire-markup ol.ref-use-labels{list-style:none;margin-left:.5em;}.highwire-markup ol.cit-list{font-size:0.9em;margin-left:2.5em;padding-left:0;}.highwire-markup ol.cit-list li{display:list-item;padding:.3em 0;}.highwire-markup div.ref-list .rev-xref-ref,.highwire-markup div.ref-list .rev-xref-ref:link{border:0;text-decoration:none;}.highwire-markup div.ref-cit,.highwire-markup .ref-cit div,.highwire-markup .ref-cit cite,.highwire-markup .ref-cit ol,.highwire-markup .ref-cit li,.ui-cluetip-content div.ref-cit,.ui-cluetip-content .ref-cit div,.ui-cluetip-content .ref-cit cite,.ui-cluetip-content .ref-cit ol,.ui-cluetip-content .ref-cit li{display:inline;margin-left:0;margin-right:0;padding-left:0;padding-right:0;}.ui-cluetip-content dd{margin-bottom:0;}.highwire-markup div.ref-cit .cit-metadata li,.ui-cluetip-content div.ref-cit .cit-metadata li{display:inline;}.highwire-markup ol.cit-list li,.ui-cluetip-content ol.cit-list li{display:list-item;padding:.3em 0;}.highwire-markup div.ref-cit cite,.ui-cluetip-content div.ref-cit cite{font-style:normal;}.highwire-markup div.ref-cit .cit-vol,.ui-cluetip-content div.ref-cit .cit-vol{font-weight:bolder;}.highwire-markup div.ref-cit div.cit-extra a,.ui-cluetip-content div.ref-cit div.cit-extra a{display:inline-block;font-size:88%;margin-left:0.75em;text-decoration:underline;vertical-align:middle;white-space:nowrap;}.highwire-markup div.ref-cit cite span.cit-source,.highwire-markup div.ref-cit cite abbr.cit-jnl-abbrev,.ui-cluetip-content div.ref-cit cite span.cit-source,.ui-cluetip-content div.ref-cit cite abbr.cit-jnl-abbrev{margin-right:.1em;font-style:italic;}.affiliation-list-reveal a.view-more{border:0;display:block;font-size:1.5em;line-height:0.9em;padding:0 5px;}.affiliation-list-reveal a.view-more{float:left;margin:0 5px;padding:0;text-align:center;width:0.9em;}.hw-article-citation div{font-size:0.9em;}.hw-article-citation div + div{margin-top:10px;}.hw-article-citation .citation-info{padding:0 5px 0 0;}.hw-article-citation .doi,.hw-article-citation .cit-date,.hw-article-citation .page-num{font-weight:bold;}.page-num .first-page + .last-page:before{content:" - ";}.orig-source{text-align:center;}.table-expansion{overflow:auto;width:100%;}.table-image-expansion{overflow:visible;}.table-expansion table{font-family:monospace;}.table-expansion table thead{font-weight:bold;background-color:whitesmoke;}.table-expansion table th,.table-expansion table td{border:1px solid lightgrey;}.table-center{text-align:center;}.table-expansion .highwire-figure + .table-caption{margin-top:10px;}.table-placeholder [class^="icon-"],.table-placeholder [class*=" icon-"]{padding-right:5px;vertical-align:middle;}sup,sub,.nlm-sup,.nlm-sub{font-size:0.75em;position:relative;bottom:0.5em;}sub,.nlm-sub{bottom:-0.5em;}.cit-ref-sprinkles{margin-left:10px;}ol.duplicate{display:none;}.underline{text-decoration:underline;}.highwire-markup .highwire-journal-article-marker-start + .auto-clean > span[style]:first-child{font-family:inherit !important;font-size:100% !important;}.highwire-markup .disp-formula-label,.highwire-markup .MathJax_Display{font-size:14px;margin-bottom:10px;}.highwire-markup .disp-formula-label{text-align:right;display:block;}.highwire-markup .disp-formula-label::before{content:'(';}.highwire-markup .disp-formula-label::after{content:')';}.highwire-markup .inline-formula img.highwire-embed{vertical-align:middle;}.highwire-markup .disp-formula{display:block;text-align:center;}
.panel-flexible .panel-separator{margin:0 0 1em 0;}
.block-nice-menus{line-height:normal;z-index:10;}ul.nice-menu,ul.nice-menu ul{z-index:5;position:relative;}ul.nice-menu li{position:relative;}ul.nice-menu a{display:block;color:#027ac6;}ul.nice-menu ul,#header-region ul.nice-menu ul{position:absolute;visibility:hidden;}ul.nice-menu li.over ul{visibility:visible;}ul.nice-menu ul li{display:block;}ul.nice-menu:after{content:".";display:block;height:0;clear:both;visibility:hidden;}ul.nice-menu li:hover ul,ul.nice-menu li.menuparent li:hover ul,ul.nice-menu li.menuparent li.menuparent li:hover ul,ul.nice-menu li.menuparent li.menuparent li.menuparent li:hover ul,ul.nice-menu li.over ul,ul.nice-menu li.menuparent li.over ul,ul.nice-menu li.menuparent li.menuparent li.over ul,ul.nice-menu li.menuparent li.menuparent li.menuparent li.over ul,#header-region ul.nice-menu li:hover ul,#header-region ul.nice-menu li.menuparent li:hover ul,#header-region ul.nice-menu li.menuparent li.menuparent li:hover ul,#header-region ul.nice-menu li.over ul,#header-region ul.nice-menu li.menuparent li.over ul,#header-region ul.nice-menu li.menuparent li.menuparent li.over ul{visibility:visible;}ul.nice-menu li:hover ul ul,ul.nice-menu li:hover ul ul ul,ul.nice-menu li:hover li:hover ul ul,ul.nice-menu li:hover li:hover ul ul ul,ul.nice-menu li:hover li:hover li:hover ul ul,ul.nice-menu li:hover li:hover li:hover ul ul ul,ul.nice-menu li.over ul ul,ul.nice-menu li.over ul ul ul,ul.nice-menu li.over li.over ul ul,ul.nice-menu li.over li.over ul ul ul,ul.nice-menu li.over li.over li.over ul ul,ul.nice-menu li.over li.over li.over ul ul ul,#header-region ul.nice-menu li:hover ul ul,#header-region ul.nice-menu li:hover ul ul ul,#header-region ul.nice-menu li:hover li:hover ul ul,#header-region ul.nice-menu li:hover li:hover ul ul ul,#header-region ul.nice-menu li:hover li:hover li:hover ul ul,#header-region ul.nice-menu li:hover li:hover li:hover ul ul ul,#header-region ul.nice-menu li.over ul ul,#header-region ul.nice-menu li.over ul ul ul,#header-region ul.nice-menu li.over li.over ul ul,#header-region ul.nice-menu li.over li.over ul ul ul,#header-region ul.nice-menu li.over li.over li.over ul ul,#header-region ul.nice-menu li.over li.over li.over ul ul ul{visibility:hidden;}ul.nice-menu li.menuparent ul,#header-region ul.nice-menu li.menuparent ul{overflow:visible !important;}ul.nice-menu li.menuparent ul iframe,#header-region ul.nice-menu li.menuparent ul iframe{display:none;display:block;position:absolute;top:0;left:0;z-index:-1;filter:mask();width:20px;height:20px;}